Kontrolle vernachlässigter Tropen- und Armutskrankheiten

Im Zentrum dieses Bereichs stehen Entwicklung, Test, Implementierung und Monitoring von Ansätzen zur Kontrolle von vernachlässigten Tropenkrankheiten (Neglected Tropical Diseases, NTDs) und Armutskrankheiten. Die Universität Basel ist zusammen mit dem Swiss TPH und weiteren assoziierten Instituten sowie Verbindungen zur Industrie führend in der produktorientierten Forschung in diesem Bereich. Durch das Zusammenspiel von innovativer Grundlagenforschung und präklinischen Studien tragen wir zum Entwicklungsprozess von Impfstoffen, Medikamenten und Diagnostik mit Fokus auf NTDs und Armutskrankheiten bei. Um neuartige Interventionen zu testen, führen wir gemeinsam mit Partnern in Afrika klinische Studien der Phasen I bis IV durch.

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Projekte

Research project

Establishment of a pan-nematode drug development platform

The consortium establishes a R&D pipeline for anthelminthics targeting nematodes. The focus will be on soil-transmitted helminthiasis and onchocerciasis, since these infections are among the leading neglected tropical diseases.

Research project

ePOCT - Smartphone-based Clinical Decision Support Tool

To improve diagnosis and care of sick children, Swiss TPH developed a smartphone-based interactive decision support tool. ePOCT guides health workers through the entire consultation and recommends treatment based both on clinical signs as well as point-of-care test results.

Research project

Bioko Island Malaria Elimination Project

The Bioko Island Malaria Elimination Project (BIMEP) addresses malaria morbidity and mortality affecting the population living and working on Bioko Island in Equatorial Guinea, and informs a broader malaria control strategy for the rest of the African continent.

Forschungsprojekt

Safety And Immunogenicity Of Novel Candidate Blood-Stage Malaria Vaccine P27A With Alhydrogel

Further research and optimisation of new malaria vaccines and technologies is ongoing at Swiss TPH. This includes testing of new candidates in Africa such as P27a.

TB Research in the BSL3-Laboratory at Swiss TPH

Forschungsprojekt

Evolution and Epidemiology of Rifampicin-Resistant Tuberculosis in Khayelitsha, Cape Town

This project uses next-generation whole genome sequencing (WGS) to study the evolution and epidemiology of DR-TB in Khayelitsha, a high HIV, TB and DR-TB burden setting in South Africa.