Kontrolle vernachlässigter Tropen- und Armutskrankheiten

Im Zentrum dieses Bereichs stehen Entwicklung, Test, Implementierung und Monitoring von Ansätzen zur Kontrolle von vernachlässigten Tropenkrankheiten (Neglected Tropical Diseases, NTDs) und Armutskrankheiten. Die Universität Basel ist zusammen mit dem Swiss TPH und weiteren assoziierten Instituten sowie Verbindungen zur Industrie führend in der produktorientierten Forschung in diesem Bereich. Durch das Zusammenspiel von innovativer Grundlagenforschung und präklinischen Studien tragen wir zum Entwicklungsprozess von Impfstoffen, Medikamenten und Diagnostik mit Fokus auf NTDs und Armutskrankheiten bei. Um neuartige Interventionen zu testen, führen wir gemeinsam mit Partnern in Afrika klinische Studien der Phasen I bis IV durch.

News

22. April 2021 / Forschung

Verbesserte Behandlung tropischer Wurmkrankheiten: ERC Advanced Grant für Jennifer Keiser

22. March 2021 / Forschung

New project: Novel Diagnostics to Improve Migrant and Refugee Health

11. May 2020 / News, People

Swiss TPH supports Diagnostic Lab for Sars-CoV-2 in Equatorial Guinea

Events

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Projekte

Research project

Establishment of a pan-nematode drug development platform

The consortium establishes a R&D pipeline for anthelminthics targeting nematodes. The focus will be on soil-transmitted helminthiasis and onchocerciasis, since these infections are among the leading neglected tropical diseases.

Research project

ePOCT - Smartphone-based Clinical Decision Support Tool

To improve diagnosis and care of sick children, Swiss TPH developed a smartphone-based interactive decision support tool. ePOCT guides health workers through the entire consultation and recommends treatment based both on clinical signs as well as point-of-care test results.

Research project

Bioko Island Malaria Elimination Project

The Bioko Island Malaria Elimination Project (BIMEP) addresses malaria morbidity and mortality affecting the population living and working on Bioko Island in Equatorial Guinea, and informs a broader malaria control strategy for the rest of the African continent.

Forschungsprojekt

Safety And Immunogenicity Of Novel Candidate Blood-Stage Malaria Vaccine P27A With Alhydrogel

Further research and optimisation of new malaria vaccines and technologies is ongoing at Swiss TPH. This includes testing of new candidates in Africa such as P27a.

TB Research in the BSL3-Laboratory at Swiss TPH

Forschungsprojekt

Evolution and Epidemiology of Rifampicin-Resistant Tuberculosis in Khayelitsha, Cape Town

This project uses next-generation whole genome sequencing (WGS) to study the evolution and epidemiology of DR-TB in Khayelitsha, a high HIV, TB and DR-TB burden setting in South Africa.

Guirou, Etienne, Tobias Schindler, Salome Hosch, Olivier Tresor Donfack, Charlene Aya Yoboue, Silvan Kraehenbuehl, Anna Deal, Glenda Cosi, Linda Gondwe, Grace Mwangoka, Heavenlight Masuki, Nahya Salim, Maxmillian Mpina, Jongo Said, Salim Abdulla, Stephen Hoffman, Bonifacio Manguire Nlavo, Carl Maas, Carlos Cortes Falla, Wonder Phiri, Guillermo Garcia, Marcel Tanner, and Claudia Daubenberger. 2020. “Molecular Malaria Surveillance Using a Novel Protocol for Extraction and Analysis of Nucleic Acids Retained on Used Rapid Diagnostic Tests”. Scientific Reports. London: Scientific Reports. doi:10.1038/s41598-020-69268-5. edoc | Open Access

Patel, Chandni, Jean T. Coulibaly, Jessica D. Schulz, Yves N’Gbesso, Jan Hattendorf, and Jennifer Keiser. 2020. “Efficacy and Safety of Ascending Dosages of Albendazole Against Trichuris Trichiura in Preschool-Aged Children, School-Aged Children and Adults: A Multi-Cohort Randomized Controlled Trial”. EClinicalMedicine 22. Elsevier : 100335. doi:10.1016/j.eclinm.2020.100335. edoc | Open Access

Krähenbühl, Silvan, Fabian Studer, Etienne Guirou, Anna Deal, Philipp Mächler, Salome Hosch, Maximilian Mpina, Sarah Mswata, Claudia Daubenberger, and Tobias Schindler. 2020. “ELIMU-MDx: A Web-Based, Open-Source Platform for Storage, Management and Analysis of Diagnostic QPCR Data”. Biotechniques 68 (1): 22-27. doi:10.2144/btn-2019-0064. edoc

Fink, Günther, Valérie D’Acremont, Hannah H. Leslie, and Jessica Cohen. 2020. “Antibiotic Exposure Among Children Younger Than 5 Years in Low-Income and Middle-Income Countries: A Cross-Sectional Study of Nationally Representative Facility-Based and Household-Based Surveys”. The Lancet Infectious Diseases 20 (2). Elsevier: 179-87. doi:10.1016/S1473-3099(19)30572-9. edoc

Palmeirim, M. S., A. Ross, B. Obrist, U. A. Mohammed, S. M. Ame, S. M. Ali, and J. Keiser. 2020. “Informed Consent Procedure in a Double Blind Randomized Anthelminthic Trial on Pemba Island, Tanzania: Do Pamphlet and Information Session Increase Caregivers Knowledge?”. BMC Medical Ethics 21. BioMed Central: 1. doi:10.1186/s12910-019-0441-3. edoc | Open Access

Vahekeni, Nina, Pedro Menezes Neto, Malilo Kaluiji Kayimbo, Pascal Mäser, Théophile Josenando, Esperança da Costa, Jacques Falquet, and Piet Van Eeuwijk. 2020. “Use of Herbal Remedies in the Management of Sleeping Sickness in Four Northern Provinces of Angola”. Journal of Ethnopharmacology. Elsevier, 20. edoc

Keitel, Kristina, Josephine Samaka, John Masimba, Hosiana Temba, Zamzam Said, Frank Kagoro, Tarsis Mlaganile, Willy Sangu, Blaise Genton, and Valerie D’Acremont. 2019. “Safety and Efficacny of C-Reactive Protein-Guided Antibiotic Use to Treat Acute Respiratory Infections in Tanzania Children: A Planned Subgroup Analysis of a Randomized Controlled Noninferiority Trial Evaluating a Novel Electronic Clinical Decision Algorithm (ePOCT)”. Clinical Infectious Diseases 69 (11). Oxford University Press: 1926-34. doi:10.1093/cid/ciz080. edoc

Schindler, Tobias, Anna C. Deal, Martina Fink, Etienne Guirou, Kara A. Moser, Solomon M. Mwakasungula, Michael G. Mihayo, Said A. Jongo, Prosper P. Chaki, Salim Abdulla, Paulo C. Manrique Valverde, Katherine Torres, Jose R. Bijeri, Joana C. Silva, Stephen L. Hoffman, Dionicia Gamboa, Marcel Tanner, and Claudia Daubenberger. 2019. “A Multiplex QPCR Approach for Detection of Pfhrp2 and Pfhrp3 Gene Deletions in Multiple Strain Infections of Plasmodium Falciparum”. Scientific Reports 9. Springer Nature: 13107. doi:10.1038/s41598-019-49389-2. edoc | Open Access

Coulibaly, Jean T., Noemi Hiroshige, Yves K. N’Gbesso, Jan Hattendorf, and Jennifer Keiser. 2019. “Efficacy and Safety of Ascending Dosages of Tribendimidine Against Hookworm Infections in Children : A Randomized Controlled Trial”. Clinical Infectious Diseases 69 (5). Oxford University Press: 845-52. doi:10.1093/cid/ciy999. edoc

Keiser, J., and J. Utzinger. 2019. “Community-Wide Soil-Transmitted Helminth Treatment Is Equity-Effective”. Lancet 393 (10185). The Lancet: 2011-12. doi:10.1016/S0140-6736(18)32981-7. edoc | Open Access

Schindler, T. Robaina, J. Raso T. Sax, J. Mpina Bieri, L. Acuche M. Gondwe, G. Cortes L. Garcia, and C. Daubenberger C. Maas. 2019. “Molecular Monitoring of the Diversity of Human Pathogenic Malaria Species in Blood Donations on Bioko Island, Equatorial Guinea”. Malaria Journal 18. BioMed Central: 9. edoc | Open Access

Olotu, Ally, Vicente Urbano, Ali Hamad, Martin Eka, Mwajuma Chemba, Elizabeth Nyakarungu, Jose Raso, Esther Eburi, Dolores O. Mandumbi, Dianna Hergott, Carl D. Maas, Mitoha O. Ayekaba, Diosdado N. Milang, Matilde R. Rivas, Tobias Schindler, Oscar M. Embon, Adam J. Ruben, Elizabeth Saverino, Yonas Abebe, Natasha Kc, Eric R. James, Tooba Murshedkar, Anita Manoj, Sumana Chakravarty, Minglin Li, Matthew Adams, Christopher Schwabe, J. Luis Segura, Claudia Daubenberger, Marcel Tanner, Thomas L. Richie, Peter F. Billingsley, B. Kim Lee Sim, Salim Abdulla, and Stephen L. Hoffman. 2018. “Advancing Global Health through Development and Clinical Trials Partnerships: A Randomized, Placebo-Controlled, Double-Blind Assessment of Safety, Tolerability, and Immunogenicity of Plasmodium Falciparum Sporozoites Vaccine for Malaria in Healthy Equatoguinean Men”. American Journal of Tropical Medicine and Hygiene 98 (1). American Society of Tropical Medicine and Hygiene: 308-18. doi:10.4269/ajtmh.17-0449. edoc | Open Access